[ashtonJ]

Hello everyone,

I am working on developing an in silico model to mimic complex and dynamic nature of coronary arteries. To do so, I need to combine different computational modules, as listed below, in one computer model:

1. Computational fluid dynamics (CFD) for modelling haemodynamics
2. Fluid structure interaction (FSI) for modelling the fluid and vessel wall interaction as the result of blood pressure waveform
3. Moving-boundary method for modelling cardiac and respiratory motions
4. Multiphase flow for modelling blood plasma and morphological elements of blood
5. Particle transport model for modelling mass transport of low density lipoproteins and other blood species to simulate genesis and progression of diseases like atherosclerosis

As far as I know using ANSYS, COMSOL or any other closed source computational tool it is not actually possible to use all of the above modules together and have them in one computer model.

I am just wondering if it would be possible using open source software like OpenFOAM to incorporate all of the above modules in one computer model.

Can anyone please enlighten me on this, and also let me know if there are other computational modules that I also need to take into consideration.

Thanks
AshtonJ

[piu58]

I don't believe that it is the right approacht to put all the physics in one model. Use different models for different aspects of your examination.

What is the aim of your computation? To understand what in principle happens at the heart or to model the coronary arteries of an individual patient?

[ashtonJ]

Thanks for reply.

Actually my aim is to develop a comprehensive computer model which can mimic coronary arteries in every aspect.

Some questions that may be answered by having such computer model are:
The effect of moving walls on multiphase flow?
Do RBCs move differently through the vessel if there is a lot of compliance?

I've used all the above-mentioned techniques separately as part of my PhD study and during my postdoc. My focus is on coronary artery disease.

Actually I am planning to apply for a postdoctoral fellowship for which I am trying to find a fundamental research topic in the area of computational modelling with potential application in human disease. I thought that such comprehensive model can be used not only for medical application but also in many other engineering applications.

[ashtonJ]

The aim is individualized computer model.