I am trying to replicate my lab experiment that is flow over a heated flat plate at a high local reynolds number. In order to prevent pump cavitation I have to pressurize the loop to 25 PSI. When modeling this in Fluent I can set the operating pressure as such, but does that also modify the outlet pressure or do I need to set that as well from the default of zero guage?

thanks

The outlet pressure will certainly affected by the operating pressure definition. I think no caviation will appear in Flent if you don't turn the caviation model on.

however absolute pressure will go below the saturation pressure with no cav model. Using the cav model you may also see negative absolute pressure in Fluent.